ABSTRACT
Coronary artery bypass grafting (CABG) has been a standard revascularization method for three-vessel disease and left main coronary artery disease since its development in the 1950s. In recent years, with the development of basic research, clinical diagnosis, surgical instruments, and interdisciplinary work, significant progress has been made in the surgical approaches, saphenous vein graft harvesting, and secondary prevention during the perioperative period. This article reviews the surgical methods of coronary artery bypass grafting, the development status and hot issues of perioperative secondary prevention.
ABSTRACT
Objective: To assess the role of XPG, XPC, CCNH and MMS19L polymorphisms response to chemotherapy in osteosarcoma, and the clinical outcome of osteosarcoma
Methods: One hundred and sixty eight osteosarcoma patients who were histologically confirmed were enrolled in our study between January 2007 and March 2009. Genotyping of XPG, XPC, CCNH and MMS19L was performed in a 384-well plate format on the MassARRAY[registered] platform
Results: Individuals with rs2296147 TT genotype showed a better response as compared with CC genotype, with the OR [95% CI] of 3.89[1.49-10.95]. Those carrying rs29001322 TT genotype presented better response to chemotherapy, and the OR [95% CI] was as high as 12.25[2.63-121.84]. Patients carrying TT genotype of XPG rs2296147 and MMS19L rs29001322 showed a significantly longer overall survival than CC genotype, they had 0.37 and 0.31-fold risk of death when compared with wide-type of this gene
Conclusions: XPG rs2296147 and MMS19L rs29001322 are correlated with response to chemotherapy and prognosis of osteosarcoma. Our findings would provide important evidence for prognostic and therapeutic implications in osteosarcoma
ABSTRACT
<p><b>OBJECTIVE</b>To study the pathogen and characteristics of viral diarrhea in children in Changchun area.</p><p><b>METHODS</b>460 stools specimens were collected from children with acute diarrhea cured in the childrens, hospital of Changchun in 2010. Rotavirus were detected by ELISA, caliceverus and astrovirus were detected by reverse transcription-polymerase chain reactions (RT-PCR), adenovirus were detected by polymerase chain reactions (PCR).</p><p><b>RESULTS</b>A total of 460 specimens were detected. The detection rate of rotavirus, caliceverus, astrovious, adenovious respectively is 35.22%, 20.43%, 9.78%, 3.70%, the detectablerate of mixed infection is 7.61%, children under 2 years old were the major patient. The main genotypes of the virus: rotavirus (G3P[8]), caliceverus (GII-4), astrovious (type I), adenovious (Ad41).</p><p><b>CONCLUSION</b>Rotavirus is the main pathogen in Changchun. Followed by caliceverus, astrovious, adenovious.</p>
Subject(s)
Child, Preschool , Female , Humans , Infant , Male , Adenoviruses, Human , Caliciviridae , China , Epidemiology , Diarrhea , Epidemiology , Mamastrovirus , Rotavirus , Virus Diseases , EpidemiologyABSTRACT
<p><b>BACKGROUND</b>5-dihydroxyanthraquinone-2-carboxylic acid (rhein) inhibits oxidoreduction induced by reducing nicotingamide adenine dinucleotide in the mitochondria and reducing reactive oxygen species, it also suppresses lipid peroxidation in rat brain homogenates. This study was to assess the effects of anthraquinone derivatives, rhein on synaptic transmission in the rat hippocampal CA1 pyramidal cell layer by intracellular recording.</p><p><b>METHODS</b>The excitatory postsynaptic potential (EPSP) evoked by stimulation of the Schaffer collaterals in the presence of bicuculline (15 micromol/L) was depressed by application of rhein (0.3 - 30 micromol/L). The amplitude of the EPSP was restored within 20 minutes after removal of rhein from the supernatant. At a concentration of 30 micromol/L, rhein reduced the amplitude of the EPSP to 42% +/- 3.7% (n = 24) of the control. Subsequently, wavelet spectral entropy was used to analyze the EPSP.</p><p><b>RESULTS</b>A strong positive correlation was observed between the wavelet spectral entropy and other parameters such as amplitude, slope of rising phase and slope of descending phase of the EPSP. The paired-pulse facilitation (PPF) of the EPSP was significantly increased by rhein (30 micromol/L). The inhibitory postsynaptic potential (IPSP) recorded in the presence of CNQX (20 micromol/L) and APV (40 micromol/L) is not altered by rhein (30 micromol/L).</p><p><b>CONCLUSIONS</b>Rhein (30 micromol/L) can decrease the frequency but not the amplitude of the miniature EPSP (mEPSP). It is suggested that rhein inhibits excitatory synaptic transmission by decreasing the release of glutamate in rat hippocampal CA1 pyramidal neurons.</p>